One orange signal indicates one copy of the 8 chromosome.

Detects trisomy 8 in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), the most common numerical abnormality in all AML subtypes. Used for enumeration of chromosome 8 copy number in hematologic malignancies through interphase nucleus analysis. Essential for identifying chromosomal gains with prognostic significance and assists in detecting cryptic abnormalities missed by conventional cytogenetics.