The EPOR gene is located on chromosome 19p13.2. The EPOR Break Apart FISH probe is designed to label both ends of the EPOR gene, respectively. A 600 Kb orange probe is designed at the 3′ end of the EPOR gene, and a 1000 Kb green probe is designed at the 5′ end of the EPOR gene.

Detects IGH-EPOR fusion in BCR-ABL1-like acute lymphoblastic leukemia, a high-risk ALL subtype with poor prognosis. Identifies EPOR rearrangements leading to increased EPOR expression and activated kinase signaling. Used for diagnosing rare cytokine receptor alterations in treatment-resistant ALL cases requiring targeted therapy approaches.